From Newsgroup: talk.origins

https://www.cidrap.umn.edu/pandemic-influenza/quick-takes-pandemic-flu-preparedness-multiple-pathogen-dashboard-more-measles

https://www.paho.org/en/news/12-5-2026-paho-signs-agreement-reserve-pandemic-influenza-vaccine-supply-latin-america-and

The Pan American Health Organization has signed an agreement with CSL
Seqirus to provide influenza vaccine for the next pandemic. They want
to learn from Covid, and have contracts in place for vaccine production,
but they are relying on a conventional influenza vaccine manufacturer,
and convention influenza vaccines are notorious for making a vaccine
that is not effective against the infecting virus. Likely the worst
case was the swine flu vaccine of the 1970's that missed the swine flu
virus and even had negative side effects and killed patients.

So even though they mention Covid in their press release it looks like
they are not going to go with an mRNA vaccine that would match the
pandemic virus and instead rely on conventional vaccines. This seems
like a stupid idea. For an mRNA vaccine all they need to do is
reprogram the mRNA sequence to be produced and make as much as they
want. For conventional vaccine they pick among their library of vaccine strains of the virus for a close relative to the infecting virus and
make vaccine that they hope will work. They do not culture the
infecting virus, purify it, then mass produce it by chick embryo
innoculation and purify the viral antigens. There are even attenuated
live virus flu vaccines, but that would not be an option for a pandemic
virus. For the Dairy epidemic as a safety measure they picked a vaccine strain of H5N1 and made hundreds of thousands of doses just in case
Human to human infection started, but by the time that Missouri patient
was infected by the dairy virus the sequence of the dairy virus was
believed to be different enough from the vaccine strain of H5N1 to not
do much good.

Ron Okimoto

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