please see release notes:
https://downloads.isc.org/isc/bind9/9.16.3/RELEASE-NOTES-bind-9.16.3.html
This is listed in Known Issues for BIND 9.16.1:
rCo UDP network ports used for listening can no longer simultaneously be used for sending traffic. An example configuration which triggers this issue would be one which uses the same address:port pair for listen-on(-v6) statements as for notify-source(-v6) or transfer-source(-v6). While this issue affects all operating systems, it only triggers log messages (e.g. "unable to create dispatch for reserved port") on some of them. There are currently no plans to make such a combination of settings work again.
please see release notes: https://downloads.isc.org/isc/bind9/9.16.3/RELEASE-NOTES-bind-9.16.3.html
If I do a full 'rndc reload' I finally get an error:
May 26 11:08:14 ludvigsen named[25953]: unable to create dispatch for reserved >port 129.242.5.254#53: permission denied
Since this is a host with serveral virtual interfaces this address/port is set >in named.conf:
transfer-source 129.242.5.254 port 53;
The solution was to remove the 'port 53' part of the config,
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