Thermo Fisher Applied Biosystems Genetic Analyzers

View CSAF
Summary
Successful exploitation of this vulnerability could allow an attacker to modify .fsa/.hid output files, tampering with DNA data and resulting in inaccurate test results.
The following versions of Thermo Fisher Applied Biosystems Genetic Analyzers are affected:

Applied Biosystems 3500/3500xL Series Data Collection Software <=4.0.2 Applied Biosystems 3730/3730xL Series Data Collection Software <=5.0.2 Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software <=1.2.5 Applied Biosystems SeqStudio Flex Series Instrument Software <=1.2.0 Applied Biosystems GeneMapper ID-X Software <=v1.7.3 Applied Biosystems 3130 Series Data Collection Software <=4.1 ABI PRISM 3100/3100-Avant Data Collection Software <=2.0
ABI PRISM 310 Data Collection Software <=3.1





CVSS
Vendor
Equipment
Vulnerabilities




v3 8.4
Thermo Fisher
Thermo Fisher Applied Biosystems Genetic Analyzers Missing Support for Integrity Check




Background

Critical Infrastructure Sectors: Healthcare and Public Health Countries/Areas Deployed: Worldwide Company Headquarters Location: United States


Vulnerabilities

Expand All +

CVE-2026-17583

The affected product is vulnerable because its .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes. View CVE Details

Affected Products
Thermo Fisher Applied Biosystems Genetic Analyzers

Vendor:Thermo Fisher
Product Version:Thermo Fisher Applied Biosystems 3500/3500xL Series Data Collection Software: <=4.0.2, Thermo Fisher Applied Biosystems 3730/3730xL Series Data Collection Software: <=5.0.2, Thermo Fisher Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software: <=1.2.5, Thermo Fisher Applied Biosystems SeqStudio Flex Series Instrument Software: <=1.2.0, Thermo Fisher Applied Biosystems GeneMapper ID-X Software: <=v1.7.3, Thermo Fisher Applied Biosystems 3130 Series Data Collection Software: <=4.1, Thermo Fisher ABI PRISM 3100/3100-Avant Data Collection Software: <=2.0, Thermo Fisher ABI
PRISM 310 Data Collection Software: <=3.1
Product Status:known_affected


Remediations
MitigationThermo Fisher has developed security updates to address the vulnerability. The security updates implement the use of digital signatures on the instrument software that adds an extralayer of protection. Moving forward, this will help users verify that data files have not been modified. Vendor fixApplied Biosystems 3500/3500xL Series Data Collection Software: Update to version 4.0.3https://downloads.thermofisher.com/3500_DCS_v4.0.3_Patch
/v4.0.3_Patch_Installer.exe
Vendor fixApplied Biosystems 3730/3730xL Series Data Collection Software: Update to version 5.0.3https://downloads.thermofisher.com/3730xl_UDC_v5.0.3_Pat ch/3730xl_UDC_v5.0.3_Patch.exe
Vendor fixApplied Biosystems SeqStudio Genetic Analyzer Data Collection Software: Update to version 1.2.6https://downloads.thermofisher.com/SeqStudio/1 .2.6/SeqStudio-1.2.6.abpkg
Vendor fixApplied Biosystems SeqStudio Flex Series Instrument Software: Update to version 1.2.1https://downloads.thermofisher.com/SeqStudioFlex/1.2.1/SeqStudi oFlex-1.2.1.abpkg
Vendor fixApplied Biosystems GeneMapper ID-X Software: Update to version 1.7.4https://downloads.thermofisher.com/GeneMapperID-Xv1.7.4_Patch/GMIDX_v1.7.4
_Patch.exe
Vendor fixApplied Biosystems 3130 Series Data Collection Software: Product is End of Life (EoL), no update provided Vendor fixABI PRISM 3100/3100-Avant Data Collection Software: Product is End of Life (EoL), no update provided
Vendor fixABI PRISM 310 Data Collection Software: Product is End of Life (EoL), no update provided
MitigationFor users who are unable to immediately implement all applicable security updates, Thermo Fisher Scientific recommends implementing the following interim mitigation measures until the applicable updates have been installed:
-Maintain a secure chain of custody for files generated by the HID instrumentation throughout the analysis workflow.-Store generated files on encrypted, password-protected storage media (for example, encrypted USB drives or encrypted hard drives).-Restrict access to generated files to authorized personnel in accordance with your laboratory's access control policies.-Apply the principle of least privilege by limiting user permissions on systems operating the HID instrumentation or hosting associated data analysis and secondary analysis software.-Leverage firewall rules and network access control lists (NACLs) to restrict internet connectivity to only trusted sources. MitigationFor more information, refer to Thermo Fisher's security bulletin.https://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_
hid_bulletin.pdf

Relevant CWE: CWE-353 Missing Support for Integrity Check

Metrics




CVSS Version
Base Score
Base Severity
Vector String




3.1
8.4
HIGH
CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H


4.0
8.2
HIGH
CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:N/SC:N/SI:H/SA:N








Acknowledgments

Nathaniel Adams, Laura Gaydosh-Combs, and Kevin Dyer reported this vulnerability to CISA


Legal Notice and Terms of Use
This product is provided subject to this Notification (https://www.cisa.gov/notification) and this Privacy & Use policy (https://www.cisa.gov/privacy-policy).

Recommended Practices
CISA recommends users take defensive measures to minimize the risk of exploitation of this vulnerability. Minimize network exposure for all control system devices and/or systems, ensuring they are not accessible from the internet. When remote access is required, use more secure methods, such as Virtual Private Networks (VPNs), recognizing VPNs may have vulnerabilities and should be updated to the most current version available. Also recognize VPN is only as secure as the connected devices.
CISA reminds organizations to perform proper impact analysis and risk assessment prior to deploying defensive measures. CISA also provides a section for control systems security recommended practices
on the ICS webpage on cisa.gov/ics. Several CISA products detailing cyber defense best practices are available for reading and download, including Improving Industrial Control Systems Cybersecurity with Defense-in-Depth Strategies.
CISA encourages organizations to implement recommended cybersecurity strategies for proactive defense of ICS assets. Additional mitigation guidance and recommended practices are publicly available on the ICS webpage at cisa.gov/ics in the technical information paper, ICS-TIP-12-146-01B--Targeted Cyber Intrusion Detection and Mitigation
Strategies.
Organizations observing suspected malicious activity should follow established internal procedures and report findings to CISA for tracking and correlation against other incidents.
No known public exploitation specifically targeting this vulnerability has been reported to CISA at this time. This vulnerability is not exploitable remotely.

Revision History

Initial Release Date: 2026-08-04




Date
Revision
Summary




2026-08-04
1
Initial Publication




Legal Notice and Terms of Use

https://www.cisa.gov/news-events/ics-medical-advisories/icsma-26-216-01

2026-08-04 12:00 UTC

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