I've wanted to give TrueCrypt/VeraCrypt a try for several whiles, but am terrified I'll mess it up and cause data loss. :D
I've been using it for years now for pretty sensitive data and I've never had any problems, including a few times I had a volume mounted and the power went out.
As for user error, it's pretty much a mount-volume-and-forget-it kind of affair, but I don't use it for whole drive encryption, just containers.
I'm actually impressed with how simple and reliable it is, even though I could just use LUKS. The benefit of Veracrypt is its volumes will mount on both Linux and Windows easily.
--- Mystic BBS v1.12 A48 (Linux/64)
* Origin: Shipwrecks & Shibboleths [San Francisco, CA - USA] (700:100/72)